[World Now] Corona vaccine, even if two drugs are mixed and right?

* “Catch Corona 19″… Formation of’Vaccine Avengers’?

“This is a fight for the fate of mankind. We will win. No matter what!” (From the movie’Avengers: Endgame dialogue)

Fight against huge enemies that are difficult to deal with alone.

‘Super Heroes’ such as Captain America and Iron Man have united.

Even in a situation where people struggle, they combine their strengths and ultimately save humanity.

As I watched the’war’ against Corona 19 taking place around the world, the movie’Avengers’ suddenly came to mind.

* One year of the war against Corona… ‘Vaccine Hero’ appeared *

Pfizer, Modena, AstraZeneca, Janssen, Novavacs, Russia’s Sputnik V, etc. from advanced Western countries such as the United States, Germany and the United Kingdom.

One year after the Corona 19 invasion, a number of multinational vaccine’superheroes’ have already appeared.

But for a while he cheered, saying,’I can finally see the light at the end of the dark tunnel.’

Various mutant viruses with much stronger spreading power have appeared in Britain, South Africa, and Brazil, and the war against Corona has entered the second round.

*’AstraZeneca + Pfizer’… Recruiting for’mixed vaccination’ clinical trials*

As the situation was like this, I even came up with the idea to pack a’Vaccine Avengers’ and do a’mixed vaccination’.

A team at Oxford University, UK, who jointly developed the vaccine with AstraZeneca, is recruiting 820 volunteers (over 50 years old) for a’mixed vaccination’ clinical trial.

We are going to get a mixture of Pfizer and AstraZeneca vaccines.

The clinical trial proceeds like this.

The first round is AstraZenecan or Pfizer vaccine.

The second injection is given within 12 weeks after the first vaccination. Some of the volunteers receive the same vaccine as the first dose and others receive the other vaccine.

After that, we plan to collect blood from the inoculum to check the amount of neutralizing antibodies and immune cells called’T cells’ against the Corona 19 virus.

The study, supported by the UK government, is expected to produce clinical results around June.

The Oxford University research team is planning a’mixed vaccination’ clinical trial with the Russian vaccine’Sputnik V’.

* Some argue that “mixed vaccinations respond better to mutant viruses”

Some, but some experts argue that’mixed vaccination’ maximizes the benefits of different vaccines, making them more resistant to mutant viruses, etc.

Let’s look at the case of AstraZeneca and Pfizer vaccines.

AstraZeneca vaccine further activates T cells, which directly kill virus-infected cells,

Pfizer vaccines are known to have the advantage of further activating the neutralizing antibody response, which prevents them from sticking to the virus and invading cells.

Based on this, the researchers hope that using the two vaccines together will increase efficacy through different types of immune responses.

Professor Matthew Snape of the University of Oxford, who leads the study, told The Guardian, “There is a possibility that the immune effect against the mutant virus is greater if one person is given a different vaccine consecutively.”

“If the results show that vaccines from different companies can be mixed, the flexibility of distribution and supply of vaccines will be greatly improved,” he said. “It could be a clue to finding out how to expand the scope of protection against mutant viruses.” .

Researchers have already conducted’mixed vaccination’ experiments on animals.

“In a study in mice, there was evidence that a combination of AstraZeneca’s vaccine and Pfizer’s vaccine could lead to a better immune response,” Snape added.

In an interview with Nature magazine, South Korean Catholic University professor Nam Jae-hwan expressed the opinion that the method of matching AstraZeneca and NovaVax is more advantageous than inoculating a mixture with Pfizer.

Professor Nam explained, “The NovaVax vaccine induces an immune response similar to that of the Pfizer vaccine, but it is easier to produce and distribute.”

* Voices worrying about “hasty attempt without data”

However, there are also voices of concern.

In an interview with the New York Times, vaccination expert John Moore of Cornell University, told the New York Times that “there is no data to prove,” and the British government “has completely abandoned the science.”

The CDC of the US Centers for Disease Control and Prevention also has a negative position on vaccine mixing.

CDC said, “There is no confirmed fact about the safety or effectiveness when using a mixture of vaccines,” and “two doses of the vaccine must be completed with the same product.”

*”‘Mixed vaccination’ is the’instruction of childbirth’ caused by insufficient quantity*

Anyway, the biggest reason why’mixed vaccination’ or’cross vaccination’ is attempted is due to insufficient quantity.

Most of the vaccines currently developed require the same company’s product to be hit twice.

Two doses are given 3 to 4 weeks after being hit once.

However, since the amount of water is insufficient, there are frequent cases where two vaccinations are given a long time after the first injection.

In some countries, such as Spain and France, vaccination has been stopped.

For this reason, England’s Public Health Department recently recommended that’if a citizen came to do the second dose and there is no vaccine for the first dose, another company’s vaccine may be taken’.

If you can get another company’s injection for the second dose, the vaccination rate could be much faster.

Even the CDC in the United States changed its’inoculation guidelines’ in mid-January as the vaccine shortage became serious.

“In exceptional cases, such as a limited supply or an unknown previously given vaccine, you can only get a combination dose,” he said.

However, CDC admits that “the two products (Pfizer and Modena) are not compatible with each other. How the new recommendations will affect the safety and efficacy of the two vaccines has not yet been studied,” admitted that patients receive the same vaccine as much as possible. He said he had to make every effort to do it.