Researchers in Korea have revealed the mechanism of development

Researchers in Korea have identified the main cause and mechanism of rheumatoid arthritis.

This research was jointly led by the National Institutes of Disease Control and Prevention (Dept. of Genetic Research and Technology Development), Bae Sang-cheol, a professor of rheumatology at Hanyang University Rheumatology Hospital, and Kim Kwang-woo, a professor at Kyunghee University’s Department of Biology. The professor participated as the co-author.

The research team has comprehensively proved a series of pathogenesis mechanisms that gene expression is regulated due to epigenetic differences due to genetic mutations in the onset of rheumatoid arthritis, and 11 causative genes associated with the onset through a large-scale multi-racial analysis of 300,000 people. Discovered for the first time in the world.

Professor Kwang-Woo Kim of Kyung Hee University said, “Through the largest research on rheumatoid arthritis genes to date, 11 new genes related to disease were discovered, reaffirmed the importance of CD4 T cells in the onset of rheumatoid arthritis, and a more sophisticated understanding of the pathogenesis mechanism I could do it,” he said.

Sang-cheol Bae, director of the Rheumatism Research Institute of Hanyang University, said, “The genetic mutations in Korean CD4 T cells regulate related genes through DNA base methylation, and through a multidimensional ohmic study, we predicted the onset and drug responsiveness of Korean patients with rheumatoid arthritis in the future. It will be possible to further develop prevention or precision medicine.”

The study was published in the online edition of the Annals of the Rheumatic Diseases, the leading academic journal in the field of rheumatism.