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[Welfare News]A study found that taking calcium drugs, which are widely used for the prevention and treatment of osteoporosis, increases the risk of cardiovascular disease (CVD) such as angina and myocardial infarction.
National Cancer Center Professor Seung-Kwon Myung, Dean of Graduate School of International Cancer Graduate University<사진>And Professor Hong-Bae Kim (co-first author) of the Department of Family Medicine at Myongji Hospital at Hanyang University recently published the results of a meta-analysis of 13 clinical trials published in international journals from 1990 to 2013. The results of this study were published last January in Nutrients (IF 4.5), an international journal of the SCIE.
As a result of the meta-analysis of the research team, it was found that the risk of CVD was 15% higher (relative risk 1.15, 95% confidence interval 1.06-1.25) than those taking placebo, a fake drug, when taking calcium drugs.
In the meta-analysis of CVD divided into coronary artery disease and cerebrovascular disease, only the risk of coronary artery disease was statistically significantly higher (relative risk 1.16, 95% confidence interval 1.05-1.28).
In addition, in the case of subjects with underlying diseases, there was no statistical significance between the use of calcium drugs and the risk of cardiovascular disease, but the risk of cardiovascular disease was statistically significantly increased in postmenopausal healthy women.
Meanwhile, related academic circles recommend that adults over 50 years of age consume 700 to 1200 mg of calcium per day for the purpose of preventing and treating osteoporosis. It is recommended to take calcium as a supplement even if intake is insufficient with food.
However, as a result of a meta-analysis of seven clinical trials in the British Medical Journal in 2010, it was reported that taking calcium drugs increased the risk of myocardial infarction by about 30%. On the contrary, in the meta-analysis paper published subsequently, it was controversial as the result that calcium drug administration was not related to cardiovascular disease risk.
Prof. Seung-kwon Myung, the lead author of the research, said, “The reason why the research results of meta-analysis papers are different is due to the selection criteria of individual papers included in the meta-analysis, the characteristics of the research subjects, and the inclusion of unpublished data.”
Professor Seung-kwon Myung continued, “This result is interpreted as a biological mechanism that suggests that when calcium is supplemented in the form of a calcium agent rather than food, the serum calcium concentration increases for a long time, which increases the risk of calcification of blood vessels, leading to cardiovascular disease. have. As another mechanism, calcium in the blood is involved in blood vessel coagulation, so excessive calcium intake can eventually increase the risk of cardiovascular disease.”
In other words, foods rich in calcium, such as milk and dairy products (yogurt, cheese, etc.), bone-eaten fish such as anchovies, deep green vegetables such as cabbage, spinach, and broccoli, and seaweed such as seaweed, seaweed, seaweed, etc. It is possible to prevent osteoporosis or fracture by regularly performing aerobic exercise such as walking or running while ingesting legumes frequently enough, and enjoying the sun for 10 minutes or more.
Professor Myung re-emphasized the clinical significance of the study, saying, “You should not eat calcium or vitamin D in the form of health functional foods or medicines.”
