Review of herbal medicines and natural products to relieve symptoms of type 2 diabetes in 65 studies in the last 5 years
It has been shown to be effective in three mechanisms: glucose transport, regulation of inflammation and oxidative stress, and lipid metabolism.
[천지일보=김빛이나 기자] Kyung Hee University (President Gyun-Tae Han) Kim Bong-i, a professor at the College of Oriental Medicine, announced on the 15th a summary of herbal medicines that were effective in treating’type 2 diabetes’.
Existing diabetes treatments were accompanied by side effects such as gastrointestinal disorders, heart failure, hypoglycemia, and pancreatitis. It is important to prevent side effects and complications of drugs due to the nature of diabetes that follows the entire life after onset. As an alternative to this, the possibility of herbal treatment has been suggested, and various herbal medicines have been studied.
Prof. Bong-I Kim’s research team who participated in this study consisted of students in the first and fourth grades of the main department. As No Seung-jin (16th grade) and Lee Jin-ju (14th grade) of Oriental Medicine became the first authors, undergraduates’ participation in the research also attracted attention.
The research results were published on January 9 in the journal’Antioxidatns (Influence Index: 5.014)’, an international academic journal at the SCIE level, as a paper entitled’Plant Extracts for Type 2 Diabetes: From Traditional Medicine to Modern Drug Discovery’.
Prof. Kim’s research team summarized the herbal treatment method for type 2 diabetes, a disease that is difficult to cure. Because type 2 diabetes is closely related to not only heredity but also wrong eating habits and lifestyle, it is possible to use oriental medicine treatment.
The research team reviewed and analyzed 65 of the studies on type 2 diabetes in the last 5 years, and identified herbal medicines that showed efficacy in treating diabetes and its mechanism. Herbal medicines have been shown to affect lipid metabolism such as glucose metabolism, inflammation and oxidative stress, and cholesterol, which are the causes of type 2 diabetes.
The research team classified herbal medicines according to the type of study by dividing them into three experimental models: cell experiments, animal experiments, and clinical trials. First, the research team looked at a total of 12 cell experiments.
Seven herbal medicinal drugs were shown to be effective in controlling glucose transport and metabolism, especially senna leaf (Cassia angustifolia Vahl) and rosemary (Rosmarinus officinalis L.), which were found to increase glucose transporter type 4 (GLUT4). Coptis chinensis franch and Hwangchil tree (Dendropanax morbifera) were found to have a reaction to eliminate inflammation.
In animal experiments, the efficacy of herbal medicines against type 2 diabetes was proven. When an herbal medicine was injected into the mice used as an experimental model, the symptoms of type 2 diabetes were significantly changed. Among the experimental rats, Litchi chinensis, mentioned more than once in 19 studies on SD rats, was found to have an effect on glucose and lipid metabolism, thereby controlling diabetes complications.
In addition, deodeok (Codonopsis lanceolata) and Yeoju (Momordica charantia L.) were found to have an effect on all three causes of diabetes.
There were 13 studies on mice called’Wistar mice’, of which Euterpe oleracea was also confirmed to have an effect on all three mechanisms. In addition, the research team confirmed that effects such as lowering blood sugar were found in animal experiments.
In the clinical trial study, the efficacy of two herbal medicines was confirmed. It was conducted in Iran and Brazil, respectively, and was a randomized, double-blind, placebo-controlled study. In a clinical study, the research team confirmed that alcoholic extract of walnut leaf (Juglans regia L.) had a significant effect on patients’ blood sugar levels and cardiovascular risk factors.
In addition, it was confirmed that green tea extract showed excellent effects in regulating blood sugar and improving lipids such as cholesterol. These results prove that herbal medicines can alleviate and treat health conditions related to diabetes.
Professor Kim Bong-i said, “This study classified herbal medicines that relieve type 2 diabetes symptoms according to the type of study subject. I hope that the research will proceed.”
Student Jinju Lee, the first author of the thesis, said, “Since diabetes is a disease that must be managed for a lifetime, I started the research because I thought that it would be better if it could be managed with herbal treatments that have fewer side effects than drugs.” “I hope there are many studies that can control diabetes in the future. There is a desire to do it.”
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