Naivek(37,900 +5.72%)Announced on the 24th that the pulmonary fibrosis treatment under development has been verified by the second efficacy test conducted by the European Commission for Clinical Trials (CRO).
This experiment validated the efficacy and safety of bleomycin-induced lung fibrosis animal models and monkeys. As a result of the experiment, data supporting the effect of treating pulmonary fibrosis were obtained. Based on this, Naivek is discussing technology introduction with a number of global pharmaceutical companies.
The European CRO compared Boehringer Ingelheim’s Ofeb, which is famous for treating idiopathic pulmonary fibrosis, with NIPEP-APF, a candidate for treating pulmonary fibrosis from Naivek. As a result of comparison by measuring the fibrotic area in the lung tissue, Naivec NIPEP-APF showed a maximum reduction of 200% or more compared to the OPEV group.
In addition, it was also confirmed that the antifibrotic function only works on the lesion tissue where fibrosis has occurred, and there is no effect on normal lung tissue.
The histopathological examination followed by the efficacy verification showed that in the animals treated with NIPEP-APF, lung fibrosis was suppressed, and the lung tissue with fibrosis recovered to a similar shape to that of normal lung tissue.
A Naivek official said, “Pulmonary fibrosis occurs when excessive collagen fibers are deposited in the lungs due to external infections or inflammation, etc.”. “NIPEP-APF is based on a mechanism that suppresses this, so the treatment efficacy is excellent but side effects do not occur. I will.” “Global pharmaceutical companies want to develop oral and inhalation formulations as well as injections.” I’m doing it.”
In the case of severe Corona 19 patients, NIPEP-APF is being evaluated as an effective treatment because the virus proliferates in the bronchi and lungs, causes pulmonary fibrosis, and increases the level of inflammatory cytokines.
Naivec is planning to begin preparing for phase 1 clinical trials starting from this verification experiment.
Reporter Minsoo Han [email protected]
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