[와이파일]”Before vaccination, this drug should be avoided… creating immunity↓”

In Korea, the COVID-19 vaccine will start sequentially starting on the 26th. There have been controversy over the efficacy and safety, but first, the vaccine will be given one after the other, starting with the priority candidates such as medical staff in charge of corona treatment.

So, what are some things we should be aware of before and after vaccination?

The World Health Organization (WHO) recommended avoiding ibuprofen-based anti-inflammatory analgesics prior to vaccination, regarding precautions for vaccination. WHO spokesman Christian Lintmeier said, “Ibuprofen can inhibit the body’s production of immune substances, so it’s a good idea to avoid it.”

Representative anti-inflammatory analgesics with ibuprofen ingredients include Advil and Blufen. These anti-inflammatory drugs, which are easily obtained and eaten when we have a fever or aches, can make the vaccine less effective. This applies not only to the corona vaccine, but also to all types of vaccines, so it is better to avoid ibuprofen-based anti-inflammatory and antipyretic drugs no matter what type of vaccination is given.

In this regard, there is an experimental result published in the Journal of Cellular Immunology by a research team at the University of Rochester, USA.

“Some anti-inflammatory analgesics suppress the formation of immunity”

It shows how the number of peripheral blood mononuclear cells (PBMCs), which are involved in the immune function of our body, changed after one week depending on which drug was administered.

It can be seen that PBMCs were the highest in cells that did not take any drug, and PBMCs were almost halved when taking ibuprofen.

Tylenol (acetaminophen) and aspirin, the other types of pain relievers we commonly use, were slightly lower when compared to when no medication was taken, but much better than when given with ibuprofen.

“Ibuprofen affects the reduction of mouse spleen immune cells”

The results were similar in the research team’s study of laboratory mice. It can be seen that the number of spleen immune cells was significantly lowered when ibuprofen was administered.

I thought about how anti-inflammatory analgesics suppress the formation of immunity in our body. When you think about how your body gets immunity, or antibodies, when you get the vaccine, you can get some answers.

“Antibody formation in the process of fighting vaccine components and immune cells in our body”

Most vaccines are made from weakened or dead bacteria or viruses that cause the disease. Because the amount of dead or weakened bacteria or viruses in the vaccine is very small, it does not enter our body and cause disease. When a vaccine made using this is injected into our body, our body’s immune cells judge them as enemies and fight hard to form immunity, that is, antibodies.

As our immune cells fight bacteria or viruses contained in the vaccine, they become inflamed and feverish. The harder our body fights, the more intense the fever and pain will be. Because of this, fever, muscle pain, inflammation and swelling at the injection site are very natural immune-building processes after vaccination.

“These symptoms mean that the immune system is active and the vaccine is working,” Rochelle Wallacek, director of the Centers for Disease Control and Prevention (CDC), also explained in a recent press briefing. “These are not side effects to worry about.”

However, in the process of fighting the vaccine or when our immune cells are about to start fighting, when an anti-inflammatory analgesic that has the effect of reducing inflammation and reducing heat comes in, the fight ends before our immune cells get enough strength. We have to fight with our strength to get enough antibodies to overcome the virus, but since there is no opportunity for that, it can be said that less immunity is generated.

If you can avoid taking ibuprofen-based anti-inflammatory analgesics before vaccination, right? Jonathan Watanabe, a professor at the University of California, Irvine, USA, said, “You should not take anti-inflammatory analgesics unless directed by your doctor. If you must take them, acetaminophen (tylenol)-based pain relievers are safer.” .

There are other opinions too. “After vaccination, acetaminophen-based drugs such as Tylenol are widely used instead of ibuprofen, which is known to have side effects, to reduce side effects such as fever and pain after vaccination,” said Professor Katie Hefer of Texas A&M Nursing University in the United States. However, drugs with this ingredient are also controversial. Some recent studies have reported that acetaminophen also slightly degrades the effectiveness of the vaccine, so its use is not prohibited, but the American Academy of Pediatrics no longer recommends the prophylactic use of acetaminophen, such as Tylenol, before vaccination.” Insisted.

“The pain, fatigue, etc. after the second vaccination is greater than the first dose”

The advice from experts to avoid taking anti-inflammatory analgesics before vaccination has another reason, besides this reducing the effectiveness of the vaccine.

Kim Woo-joo, a professor of infectious medicine at Korea University’s Guro Hospital, said, “It is rare that the adverse reactions are not fatal after vaccination, but anaphylactic shock (anaphylactic shock in response to a specific antigen. Itching, urticaria, respiratory distress, etc. “Anti-inflammatory analgesics can act as a mask for these abnormalities and can delay immediate treatment in the event of symptoms and side effects such as death in severe cases.”

Therefore, even if you take antipyretics or painkillers, you can take 15 to 30 minutes after vaccination to see if there is a serious adverse reaction and then eat as needed.

Professor Woo-Joo Kim also advised, “Since it is common for the elderly 65 years of age or older to contain such anti-inflammatory analgesics in their regular arthritis drugs, it is advisable to receive vaccination after consulting with the medical staff sufficiently before vaccination.” I did.

Among the Corona 19 vaccines secured by Korea, AstraZeneca, Modena, and Pfizer vaccines, excluding Janssen’s, all need to be vaccinated twice at intervals. In other countries that have already received these vaccinations, mild adverse reactions, such as swollen, inflamed or painful areas of the vaccination site, were mostly natural reactions in the immunity-building process, such as fever, muscle pain, and fatigue.

Like other vaccines, anaphylactic shock, a severe adverse reaction after COVID-19 vaccination, has been reported in 1 in 100,000 to 1 million people. Severe adverse reactions to be concerned about after vaccination include hives, shortness of breath, loss of consciousness, etc. In this case, you should immediately notify the hospital where you received the vaccination or call 911 to go to the emergency room.

Most of the vaccinators who have experienced two doses said, “It seems that muscle pain and fatigue are greater than when the general flu (influenza) vaccination was performed. And after the second vaccination than the first vaccination, the body was more difficult.”

Prof. Kim Woo-joo said, “The Corona 19 vaccine is the first vaccine we encounter in our lives. Since flu vaccines are correct every year, our bodies have some immunity, but the corona vaccine is the first type of vaccine we are born with, so the body feels more difficult. It’s a natural phenomenon.”

In addition, in the case of most vaccines that are vaccinated twice as well as the corona vaccine, “the first dose is the basic vaccination, and the second dose acts as a booster, so the pain or side effects are more severe after the second vaccination.” He emphasized, “Because you can only get as much antibodies as you need, you should not avoid the second dose.”

The CDC of the U.S. Centers for Disease Control and Prevention says that if you have a fever and pain at the vaccination site, you should wear a damp towel cold and put it on your arm instead of taking an antipyretic or pain reliever immediately, or if you have a fever, drink plenty of fluids and wear light clothes. I advised that things are helpful.

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