[서울신문] Pfizer, 95% prevention effect’best’… Janssen and AstraZeneca have side effects such as nervous system

Vaccine efficacy and difference Q&A of 4 overseas companies

Pfizer, Modena, fatigue, headache, allergic reactions
The price per synagogue is the cheapest in AstraZeneca

Following AstraZeneca, on the 24th, Pfizer and Janssen completed the corona 19 vaccine contract, leaving only the supply contract with Modena. The questions and answers were given to the efficacy and differences of the four vaccines that will be brought in through individual companies.

Q. What kind of vaccine are the four companies?

A. Pfizer and Modena’s nucleic acid vaccine (mRNA) is a vaccine that injects genetic material into our body to create an antigen, and from this antigen, an antibody to prevent the corona 19 virus is released. The Janssen and AstraZeneca vaccines are carrier vaccines that trigger an immune response by putting genes in viruses that are not harmful to the human body.

Q. How is the effect different?

A. As a result of the phase 3 clinical trial, the effect of preventing COVID-19 was 95% for Pfizer and 94.1% for Modena. AstraZeneca showed a 90% preventive effect when administered half of the dose and 62% when administered twice completely. The average is 70%. However, the reason why the preventive effect was higher when only half was administered has not been identified. Janssen has been conducting phase 3 clinical trials targeting 60,000 people worldwide since September, and is expected to end in the first quarter of next year. The level of efficacy has not yet been reported.

Q. Is there any risk of side effects?

A. Pfizer and Modena vaccine showed only fatigue and headache immune responses in phase 3 clinical trials. However, because each individual has a different constitution, it is not known what side effects will occur in the actual vaccination. In the UK, where the Pfizer vaccination was first started, two people had an allergic reaction of fever, rash, tachycardia, and shortness of breath within a day of vaccination.

Q. Janssen and AstraZeneca vaccines also had side effects in clinical trials.

A. AstraZeneca stopped a phase 3 clinical trial after finding’transverse myelitis’ in a clinical participant in September. In July, one clinical participant had a nervous system side effect. At the time, it lost trust from the Food and Drug Administration (FDA) by hiding the fact that the side effects occurred. AstraZeneca is again undergoing large-scale phase 3 clinical trials. The Janssen vaccine had an unknown disease in one patient who was vaccinated in October, and clinical trials were stopped at an early stage.

Q. How many times and what is the price?

A. Pfizer, Modena, and AstraZeneca are given twice, and Janssen is given one dose. The cost of one dose is Pfizer $19.5 (approximately 21.5 won), Modena $15-25 (approximately 17,000-28,000 won), AstraZeneca $3-5 (approximately 3300-5400 won), Janssen 10 It’s a dollar (about 1,900 won).

Reporter Lee Hyun-jung [email protected]